Book your next trip

Cape Girardeau is situated on a hillside, and makes a handsome appearance, the great humorist and novelist Mark Twain said of our Missouri town. From the grand sweep of the Mississippi River to our well-preserved historic downtown, Cape Girardeau remains a handsome place to this day and attracts visitors from around the world. At the Hampton Inn® hotel in Cape Girardeau, we're eager to show you around. Within just a few minutes of our Hampton Inn® hotel in Cape Girardeau, visitors may spend time in Riverfront Park, where riverboats dock. Explore our historic sites and poke around our antique shops,...