Welcome to Hampton Inn Poplar Bluff, your perfect base for exploring the heart of Missouri. Nestled in a peaceful rural setting, our hotel offers a convenient escape just a short drive from the bustling town centre. Whether you're here for business or leisure, you'll find everything you need for a comfortable and productive stay.

We're ideally situated within a 5-minute drive of the Poplar Bluff Regional Medical Centre, making us a convenient choice for those visiting or working at the facility. You're also just moments away from the historic charm of the North Main Street Historic District, offering a glimpse into...